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I have an Aussie mix and desperately needed some info on this. Thank you for this. I like Frank so much that I had to give him his own story. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). Thank you for such a great article! We do eat it! Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. The most common adverse reactions in clinical trials were vomiting . First, I want to thank you for the time and effort that went into writing this article. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) Is Simparica Safe For Dogs? However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. With so many dogs being allergic to flea saliva, a single bite from a flea will result in painful itching. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. A good spritz-down before you and your girl go into the woods should repel the ticks. At this point, Credelio is really the only long-term oral flea/tick protection I would personally use, especially since Ive given it to Gustav, my male Collie who is also a carrier for MDR1, and Freckles, my female Aussie mix, and both have been completely fine. The manufacturer of Revolution has tested the product for safety in dogs with the MDR1 mutation. The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. Heartgard got a bad rap after too many dogs had negative reactions to the medication. We are waiting for the results from her test for the MDR1 gene. Ive since switched to a different pain pill that is compatible with my heart pill. To help with this, the product can be applied in more than one line between the neck and shoulder blades. Yes, Simparica is a good flea treatment for dogs. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. She has always had a sensitive stomach, but as she gets older, it gets worse. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. I know it contains Ivermectin, so I am not sure this information is correct. Im happy to hear it and so glad it helped! We have a almost 10 year old tricolor rough collie, named Hollie. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. Please log in again. While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. Or is it when given together? I really do not know what to do and get no real input from my Vet. You can even scatter some on your dogs bed. Im trying to find out if this is safe for her. I just took her off Sentinel Flavor Tabs. This drug should be avoided in all dogs with the MDR1 mutation. Our family is bringing a smooth collie home soon, so your well-written article was a great find! Thanks Research efforts are underway to determine if new veterinary and human drug products could be problematic for dogs with the MDR1 mutation. What Can Cause Seizures in Dogs? Fleas were treated with effifax, active ingredient fipronil. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) My other vet never brought this up when discussing my MAS. Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. However, as with any chemical compounds, caution is advised even with products deemed to be safe. However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. Miscellaneous This organic powder is great for a variety of uses. My vet wants to give him a vaccine (?) If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). Coming from the house of Zoetis, Simparica is an efficient flea and tick treatment providing a gamut of benefits to both dogs and pet parents. My dogs are on Sentinel right now and Frontline Gold. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. Is Simparica safe for MDR1 dogs? Im happy to hear you found it helpful! It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. Thank you thank you thank you for this article. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. . In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. Unacceptable for me) He is MDR1 clear. Thank you for the reminder! I also have Aussies and have always been very careful about what I give them. If you'd like to know for sure if your dog carries this gene, there are genetic tests available. Before I got them home, they went into comas. Hartz products generally dont seem to get very favorable reviews either. (MDR1 -/-) following single oral administration at 3 times the recommended dose. Because of their similarity to Heartgard, Ive placed them in the same caution category. Ive had success using Burts Bees ear rinse on my dogs. Congratulations and good luck with your new dog! Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). (Of course, skin irritation can happen with any topical product.) That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. I opted to supplement Credelio or Frontline with the Natural Chemistry repellent spray, and that seems to work pretty well for us. Whether a dog reacts depends on the dosage of the drug. I give Interceptor Plus for HW, but Im conflicted about which direction to go for flea & tick. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Is this vaccine something youve heard of? Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. Wide dose range and able to treat dogs up to 60kg. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) Based on your recommendations, I will not use Vectra. I have a female 3 year old collie. Fleas this summer in my part of CA are particularly bad. Here are a few of the safest flea treatments for dogs on the market today and some of their pros and cons. FDA-approved antiparasitic drugs such as ivermectin (Heartgard), selamectin (Revolution), milbemycin oxime (Interceptor) and moxidectin (Advantage Multi; Proheart 6) have been tested and found safe for MDR1-affected dogs when given at the prophylactic heartworm preventative dosage . The effectiveness of ProHeart 12 has not been evaluated in dogs less than 12 months of age. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. (Which made him feel really sick.) I can live with that. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. We do, however, have lots of deer ticks (also known as black legged ticks). Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. Personally, I would be concerned about missing a daily dose. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. I have a one year old Aussie mix. The bottom line is, its best to avoid giving your Collie Heartgard or a similar medication. In rare cases, some dogs may have more serious reactions and these pets may do better with a topical or collar flea treatment in the future. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Could you send the link to that article you found? Best of luck! The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. Eating poison. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. We gave her the first dose in late February and there were no adverse side effects for Sugar. Hope this helps! The tail curling and pacing lasted over a week. Simparica TRIO (6.0 mg/0.12 mg/25. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). enough to have 4 dogs like I do! But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. I had never heard of Dimmitrol before, but I did some research after reading your comment. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. She was obviously in discomfort. These medications are safe and effective for most dogs, and side effects tend to be mild. Super useful research. Safe for dogs from 1.25 kg; Can be given with our without food; Pork liver flavoured chewable tablet; Safe in heartworm positive dogs; Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Heartworm. The Seresto collar is a very popular option right now. Please tell me if I am wrong. And use same collar for a few months. The safe use of SIMPARICA has not been evaluated in breeding, pregnant, or lactating dogs. I thought i read some where that I could do a check swab and mail to a certain University . And thank you for saying so. Dogs with the mutation will react to those drugs. (More on those later.). Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) Natural Chemistry claims to kill on contact and to be safe for puppies. Given at the proper doses and under the supervision of a veterinarian, ivermectin is safe for most dogs and is very effective in treating and preventing a number of parasites. We need more people like you. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. Infected dogs should be treated with an adulticide to remove adult heartworms. Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. It just depends on the individual dog. Interceptor and Sentinel are safe for Border Collies. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. I have a new Collie-mix with bi-coloured coat. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. After logging in you can close it and return to this page. Mary. So, what do you think of Parastar Plus? It has the same active ingredients as Seresto (plus one), so a bit stronger. The manufacturer's website provides this warning No adverse effects were observed. Just want to do what is best for them? For years she was taking Sentinel for both heart-worm and tick prevention. (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. ATLANTA Thousands of dog owners worldwide blame a popular flea killer for harming their pets. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. Second, Id like to ask a question if you dont mind. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. The drawback of Advantage is that it does not offer any protection against ticks. Simparica starts killing fleas within 3 hours and ticks within 8 hours, and it keeps going strong for 35 days without losing effectiveness at the end of the month. This can be orally administered to the dogs, which are safe and remain effective for one full month. However, a dog with . It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. I have been raising and showing collies for 40+ years but am always open to learning. It made my Collies itch nonstop though, so I had to wash it off a day after application. Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. They both have tolerated Bravecto very well.no noticeable side effects. Now we are out thousands of dollars when every event has been triggered by Simparica Trio. So it's very likely that the adverse effects of this chewable drug are similar to the other two drugs. Whats the best safest flea tick treatment for a collie puppy? The Vet is too expensive! I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. Veterinary pharmacologist Dr. Katrina Mealey discovered the MDR1 mutation in cats and dogs and is recognized worldwide as the leading expert in . Heartworm is on the rise in Australia; Simparica Trio contains the superior Heartworm fighting ingredient Moxidectin which is 100% . This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. Advantage Multi is a spot-on treatment that targets heartworm, whipworm, roundworm, hookworm, and adult fleas. Use with caution in dogs with a history of seizures. (MDR1 -/-) following single oral administration at 5 times the . THREE OF THE 8 FEMALES WENT INTO ESTRUS. The FDA determined ProHeart is safe for dogs with the MDR1 mutation when used at label doses. Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! For the majority of dogs, Advecta is probably fine! . (I have to give them baths with a very mild or medicated shampoo.) Thank you for your article. I would say you are right to be concerned, and Ill give some info why. Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . Liver disease. Another one that still seems to be working good is afoxolaner (Nexgard). As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. What are your thoughts on that? No adverse effects were observed. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. As more dogs are tested, more breeds will probably be added to the list of affected breeds. Hi Emily, this is a great article and I appreciate all of your research! WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. So glad you found this useful! That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. Dogs with the MDR1 mutation are not at increased risk for adverse effects. From the time that the collar went on the market in 2012 until 2020, the EPA (Environmental Protection Agency) received 1,698 reports of deceased pets. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 mutation. . 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